Meta-analysis of non-occupational physical activity and cardiovascular disease, cancer and mortality outcomes

Ali Abbas

Structure

Agenda

  • Meta-Analysis
  • Physical Activity (PA) and its relationship with diseases/mortality
  • Outcomes of interest
  • Interactive Interface
  • Code to access the dose-response curves

Meta-Analysis

What is meta-analysis?

  • Statistical technique for combining data from multiple studies on a particular topic.
  • Synthesizing evidence and summarizing the results of individual studies

The Evidence-Based Medicine Pyramid

https://uk.cochrane.org/news/meta-analysis-what-why-and-how

Meta-analysis of diseases and PA

  • Cardiovascular diseases cause 17.9 million deaths per year in 2019
  • Cancers are responsible for 9.6 million deaths in 2017

Physical Activity

  • Physical Activity is known to reduce the risk of cardiovascular diseases and cancers Garcia et al. (2023)

    dose-response paper

Interactive Interface

Outcomes - overall

1 (with some non-significant associations)

Outcomes - Level 1

Outcomes - Level 2

Outcomes - Level 3

Outcome category and type

Meta-analysis and dose-range

Dose range and Potential Impact Fraction

Code

R Package

  • An R package called dose-response physical activity is created
  • It is open source and hosted on GitHub
  • You may need to install it used remotes::install_github("meta-analyses/drpa")
# Specify the cause, outcome_type and the dose
rr <- drpa::dose_response(cause = cause_name, 
        outcome_type = outcome_type, 
        dose = float)

Code Animations

  • An R package called dose-response physical activity is created
  • It is open source and hosted on GitHub . . .

https://meta-analyses.github.io/drpa/drpa.html

Arguments

Arguments for the dose_response function

Garcia, Leandro, Matthew Pearce, Ali Abbas, Alexander Mok, Tessa Strain, Sara Ali, Alessio Crippa, et al. 2023. “Non-Occupational Physical Activity and Risk of Cardiovascular Disease, Cancer and Mortality Outcomes: A Dose–Response Meta-Analysis of Large Prospective Studies.” British Journal of Sports Medicine.